Keep your GLP-1 vials refrigerated at 36-46°F (2-8°C). Do not freeze. Store in the original carton or amber vial to protect from light. Before each use, inspect the solution — standard tirzepatide (with B6) should appear clear and/or slightly yellow, standard semaglutide (with B12) will appear pink to reddish, and additive-free (Pure) formulations will appear clear or near-colorless. Do not use if it's cloudy or has particles. If the medication appears unusual, you may need to provide photo verification to your pharmacy to assess its usability.
Refrigeration: Store vials between 36-46°F (2-8°C). Keep away from freezer vents, direct sunlight, and hot cars. Return the vial to the fridge immediately after each dose.
Unpunctured vials:
Room Temperature: Up to 60 days
95°F: Up to 15 days
104°F: Up to 5 days
If these temperature limits are exceeded, the medication may no longer be safe to use, and you should consult your pharmacist or healthcare provider for guidance.
Once punctured, refrigeration is required. If a punctured vial is exposed to adverse conditions, consult your pharmacist to determine if a replacement is necessary.
28 Day Puncture Rule
While manufacturers typically test multi-dose vials for sterility up to 28 days, pharmacies can extend this timeframe based on their own rigorous safety testing for specific medications. When you receive a multi-month supply in one vial, the pharmacy has verified it remains safe and effective for the entire treatment period.
All injectable medications have a "best used by date" due to sterility concerns, but as long as you use a new needle each week and keep the vial clean, the pharmacy and our doctors say that the medication and its potency are good for 6 months after opening. Many patients use it longer with no issues.
Beyond-Use Date (BUD)
The beyond-use date tells you how long your medication stays safe and effective in the vial. Always check the labeled BUD on your specific vial — it will be clearly printed by the pharmacy that compounded your medication. BUD varies by compounding pharmacy and formulation.
If you're unsure about the BUD on your vial, reach out to our Patient Success Team through the chat widget and we'll confirm.
My Medication Arrived Warm or at Room Temperature
Your medication is very stable. It stays perfectly good for up to 60 days at normal room temperature, and it can even handle brief heat exposure up to 104°F for up to 5 days without losing effectiveness. Brief transit without ice packs does not affect your medication's safety or effectiveness.
When to contact us:
The medication appears visibly cloudy or has particles
The package shows signs of extreme heat exposure (warped packaging, leaking)
The medication was exposed to freezing temperatures (ice crystals visible)
You're concerned about the condition of your shipment for any reason
If any of these apply, reach out to our Patient Success Team through the chat widget — do not use the medication until we've confirmed it's safe. We'll arrange a replacement if needed.
Safe handling: Clean the rubber stopper with an alcohol swab before each draw. Use a new sterile syringe and needle every time. Write the date you first punctured the vial on the label. Never share vials or needles.
Sharps disposal: Dispose of used needles and syringes in an FDA-cleared sharps container. Do not throw them in regular trash.