If it's been 4 days or less since your missed dose, take your injection as soon as you remember. If it's been more than 4 days, skip the missed dose entirely and take your next injection on your regular scheduled day. Never take two doses at once or within a few days of each other.

4 days or less: Take your injection as soon as you remember. You can keep your original weekly schedule or start a new schedule based on the day you took the late dose - whichever is easier to remember.

More than 4 days: Skip the missed dose. Resume on your regular scheduled day. Don't try to "catch up" by taking extra medication - this increases the risk of side effects like nausea without improving results.

Restarting after several weeks off: If it has been more than 8 weeks since your last dose of a GLP-1 medication, such as tirzepatide or semaglutide, it is important to restart at the standard starting dose. This ensures a safe reintroduction of the medication and minimizes the risk of side effects. Contact your care team for personalized advice and to confirm the appropriate starting dose for your situation.

For tirzepatide, if more than 8 weeks have passed since your last dose, you must restart at the standard starting dose. This precaution is necessary to ensure safety and to allow your body to reacclimate to the medication.

If more than 8 weeks have passed since your last dose of semaglutide, begin again at the introductory dosage. The medication’s half-life requires a gradual reintroduction to ensure good tolerance and to minimize potential side effects.

The gradual reintroduction of GLP-1 medications after a prolonged gap is crucial for several reasons: