GLP-1 Medications (Semaglutide and Tirzepatide)
GLP-1 medications are subcutaneous injections — meaning they go just under the skin, not into a vein or muscle.
Approved Injection Sites
Abdomen — choose a clear area on your belly with intact skin. Avoid your belly button and any scars, moles, or irritated skin.
Front of the thigh — use the upper front of your leg where there is a soft layer of fat.
Outer upper arm — use the outer back of the upper arm. Because this area is hard to reach on your own, it's best to have a partner administer this site.
Key Reminders
Rotate within each region — do not repeat the exact same spot each week
GLP-1 injections are subcutaneous only — do not inject into a vein or muscle
Avoid bruised, tender, scarred, or inflamed skin at any site
How to Rotate Sites
A simple rotation system to follow:
Week 1: Left abdomen
Week 2: Right abdomen
Week 3: Left thigh
Week 4: Right thigh
Then repeat
Keep a small note in your phone or on your medication box so you always know where you injected last.
MIC-B12 Injections
MIC-B12 is given as an intramuscular (IM) injection — into the muscle, not just under the skin. The technique and needle length are different from GLP-1 injections. Do not use the same method for both.
The Pharmacy Hub recommends administering MIC+B12 via intramuscular (IM) injection only. Subcutaneous (SQ) injection is not advised, as absorption is typically slower and less reliable, which can result in reduced effectiveness and an increased likelihood of side effects. If a subcutaneous injection was administered, the dose should be no more than half of your normally prescribed amount.
Approved Injection Sites
Outer thigh — middle third of the outer upper leg. This is the easiest site for self-injection.
Deltoid (upper arm) — middle of the outer arm, 2–3 finger widths below the shoulder. Best for volumes up to 1 mL.
Key Reminders
Insert the needle at a 90° angle
Pull back the plunger slightly before injecting to confirm you are not in a blood vessel
Rotate sides and sites with every dose — for example: right thigh, left thigh, right arm, and so on
Avoid bruised, scarred, or inflamed areas
Step-by-Step Injection Technique (Both Medications)
Wash your hands and check your medication and dose.
Choose your site and clean it with an alcohol swab. Let it dry completely before injecting.
Draw up your dose — for help with the correct amount, see our Dose Conversion Tables guide.
Inject using the correct technique for your medication (subcutaneous for GLP-1, intramuscular for MIC-B12).
Remove the needle and apply light pressure with gauze if needed.
Dispose of your needle safely in a sharps container. Do not place needles in regular trash. Many pharmacies offer sharps disposal — check with your local pharmacy.
Return your vial to the refrigerator immediately after use. Do not leave it at room temperature for extended periods.
Note your next rotation spot so you're ready for your next dose.
What if I have a reaction at my injection site?
Mild redness or slight irritation right after injecting is normal. If you notice a reaction:
Rotate away from that site for your next injection
Apply a cold compress to reduce redness or swelling
Contact your provider through the portal if the redness spreads, worsens, or doesn't resolve within a day or two
Seek immediate medical attention if you experience signs of a severe allergic reaction such as swelling, difficulty breathing, or hives
Need help with your injection technique?
If you're unsure about your technique or have questions about finding the right site for your body, contact support and we'll help you from there.