Tirzepatide and Semaglutide should ideally be stored in a refrigerator to maintain their stability and effectiveness.

If either medication is removed from the refrigerator, specific timeframes apply for stability at room temperature.

Both medications remain stable at room temperature for up to 60 days.

Tirzepatide can also handle brief heat exposure without losing effectiveness:

Tirzepatide: Remains stable for 9–12 months (depending on the batch).

Semaglutide: Remains stable for 3–6 months (depending on the batch).

Always keep both medications refrigerated when not in use.

If your medication arrives frozen or was accidentally stored in the freezer, stability studies confirm it remains safe and effective.

Simply allow it to thaw at room temperature before use, then continue storing it in the refrigerator as instructed.

The "DO NOT USE IF FROZEN" label is a precautionary measure from the manufacturer to discourage improper freezer storage — not an indication the medication is compromised if briefly frozen.

If you find a vial that was left at room temperature, refrigerate it again as soon as possible.

Ensure the medication has not exceeded its recommended room temperature stability duration before using it.

If your shipment arrived warm, check whether the vials are hot to the touch. If they are cool or only mildly warm and look normal, refrigerate them and continue as usual.

If the vials are hot to the touch, or you see cloudiness, particles, or heat-damaged packaging, do not use the medication — contact our Patient Success Team and we'll assess it and arrange a replacement if needed.