General Storage Guidelines
Tirzepatide and Semaglutide should ideally be stored in a refrigerator to maintain their stability and effectiveness.
If either medication is removed from the refrigerator, specific timeframes apply for stability at room temperature.
Stability at Room Temperature
Both medications remain stable at room temperature for up to 60 days.
Tirzepatide can also handle brief heat exposure without losing effectiveness:
Up to 30 days at room temperature
Up to 15 days at 95°F
Up to 5 days at 104°F
Stability in the Refrigerator (Beyond-Use Date)
Tirzepatide: Remains stable for 9–12 months (depending on the batch).
Semaglutide: Remains stable for 3–6 months (depending on the batch).
Always keep both medications refrigerated when not in use.
What If My Medication Was Frozen?
If your medication arrives frozen or was accidentally stored in the freezer, stability studies confirm it remains safe and effective.
Simply allow it to thaw at room temperature before use, then continue storing it in the refrigerator as instructed.
The "DO NOT USE IF FROZEN" label is a precautionary measure from the manufacturer to discourage improper freezer storage — not an indication the medication is compromised if briefly frozen.
Actions to Take if Storage Guidelines Are Not Followed
If you find a vial that was left at room temperature, refrigerate it again as soon as possible.
Ensure the medication has not exceeded its recommended room temperature stability duration before using it.
By following these guidelines, you can ensure the safety and effectiveness of both tirzepatide and semaglutide.