Short answer: Yes.

Belle offers additive-free compounded GLP-1 medications in all 50 states for patients with an allergy or sensitivity to B vitamins.

Most compounded GLP-1 medications include additional ingredients beyond the active drug — commonly B vitamins such as cyanocobalamin (B12), pyridoxine (B6), or niacinamide (B3), and sometimes other excipients like preservatives.

Belle's additive-free compounded GLP-1 contains the active medication (tirzepatide or semaglutide) without these added B vitamins or related additives. It's formulated specifically for patients who cannot tolerate standard compounded formulations due to an allergy or sensitivity.

Additive-free compounded GLP-1 is available to patients who indicate a B vitamin allergy or sensitivity on their Belle intake questionnaire. Your clinician reviews this as part of your treatment plan and routes qualifying patients to the additive-free formulation.

Important: Additive-free compounding is a clinical pathway for patients with a genuine B vitamin allergy or sensitivity — not a preference-based option.

If you're a new patient: Indicate your B vitamin allergy or sensitivity when you complete your intake questionnaire. Your clinician will factor it into your treatment plan, and you'll be routed to the additive-free formulation from your first prescription.

If you're already a Belle patient and did not indicate a B vitamin allergy during your original intake: Reply here or message your care team through the patient portal, and we'll update your record and coordinate with your clinician.

Yes. Belle ships additive-free compounded GLP-1 to patients in all 50 states through our licensed compounding pharmacy network.

Yes. The active medication is the same — tirzepatide or semaglutide — at the same prescribed dose. The only difference is the absence of added B vitamins and related excipients. Clinical outcomes depend on the active drug, not the additives.

Last updated: April 23, 2026