Proper Injection Site for GLP-1 Medicines
Getting the site right keeps dosing consistent and reduces skin irritation. GLP-1 medicines like semaglutide and tirzepatide are designed for subcutaneous injection under the skin. Approved areas include the abdomen, thigh, and upper arm. Rotate sites to protect your skin and comfort over time.
Quick Guidance
Abdomen, front of thigh, or upper arm are acceptable GLP-1 injection sites. Rotate every dose.
The upper arm is typically injected by another person since the back of the arm is hard to reach.
GLP-1 injections are subcutaneous only. Do not inject into a vein or muscle.
Approved GLP-1 Injection Sites
Abdomen: Choose a clear area on the belly with intact skin. Avoid scars, moles, or irritated skin.
Thigh: Use the front of the upper leg where there is a soft layer of fat.
Upper arm: Use the outer back of the upper arm. For accuracy and safety, have a partner administer this site.
These locations are supported across branded GLP-1 labels such as semaglutide and tirzepatide. Rotate within each region rather than repeating the exact same spot.
How to Rotate Injection Sites
Use a simple system you can remember. Example: Week 1 left abdomen quadrant, Week 2 right abdomen quadrant, Week 3 left thigh, Week 4 right thigh, then repeat. Keep a small log in your phone or medication box. Rotating helps reduce tenderness and preserves healthy skin. Label guidance recommends changing sites with each dose.
Step-by-Step Technique
Wash hands and check your medication and dose.
Choose your site and clean with an alcohol swab. Let it dry.
For vials and syringes, follow the drawing instructions provided by your care team.
Remove the needle, apply light pressure with gauze if needed, and dispose of sharps safely.
Return your medication to proper storage and note your next rotation spot.
Manufacturer materials describe the same approved body areas and emphasize subcutaneous use.
What to Avoid and When to Reach Out
Avoid bruised, tender, scarred, or recently shaved skin. Skip any site with rashes or infection. If you consistently have pain, redness that lasts, or trouble reaching the upper arm, switch to abdomen or thigh and contact your care team. GLP-1 site selection is flexible across abdomen, thigh, and upper arm, and your clinician can help tailor a rotation plan that fits your body and routine.
Need Help Now?
Send a message through your patient portal or book a same-day telehealth coaching session. Our telehealth GLP-1 support team can watch your technique on video, confirm the best GLP-1 injection site, and set up a rotation plan so you always know where to inject semaglutide or the right tirzepatide injection site for your next dose.