When you see a GLP-1 medication described as “compounded with B6” or “compounded with B12,” it means a licensed compounding pharmacy prepares the medication and includes a vitamin as part of the formulation.
At Belle:
Tirzepatide is compounded with vitamin B6
Semaglutide is compounded with vitamin B12 (methylcobalamin)
These vitamins are commonly used in compounded formulations and do not change the intended use, safety, or effectiveness of your medication.
When compounding GLP-1 medications, only the base form of Tirzepatide and Semaglutide is used — not salt forms. Belle partners exclusively with licensed, FDA-registered 503B compounding pharmacies that follow these standards.
Helpful to know: The color of your medication may look different than before.
Previously, tirzepatide was compounded with vitamin B12, which naturally gives the medication a pink or red tint. We now partner with a new compounding pharmacy (BPI) that uses vitamin B6 instead. Because B6 is clear, your tirzepatide will now appear clear or slightly yellow in color.
This change does not affect the safety, quality, or effectiveness of your medication.
How B6 Benefits You (Tirzepatide)
Vitamin B6 (pyridoxine) helps your body:
Support protein and amino acid metabolism—essential when your diet changes during weight loss
Regulate mood and brain function by helping produce neurotransmitters like serotonin and dopamine
Support immune function and help your body fight illness
Reduce nausea—B6 is commonly used to help manage nausea, which can be helpful as your body adjusts to GLP-1 therapy
Support cardiovascular health by helping regulate homocysteine levels
How B12 Benefits You (Semaglutide)
Vitamin B12 helps your body:
Make healthy red blood cells that carry oxygen—low levels can cause megaloblastic anemia with tiredness and weakness
Support nerves and DNA, helping maintain normal nerve function and cellular health
Support energy metabolism, though it does not boost energy or cause weight loss in people with adequate B12 levels
Who Benefits Most from B6 and B12
You may benefit from B6 or B12 supplementation if you:
Follow a vegan/vegetarian diet (limited natural plant sources)
Are an older adult or have GI conditions (e.g., celiac, Crohn's) affecting absorption
Have had bariatric or GI surgery
Take metformin long-term for diabetes or prediabetes (periodic B12 monitoring is recommended)
Are experiencing nausea during GLP-1 therapy (B6 may help)
How to Get B6 and B12
Diet: Poultry, fish, potatoes, bananas, and chickpeas are rich in B6. Meat, fish, eggs, and dairy are rich in B12; some cereals are fortified with both.
Supplements: Oral tablets work for many; injections are options when absorption is poor. Both vitamins are water-soluble and generally well tolerated.
Belle offers Compounded Tirzepatide with B6 and Semaglutide with B12. These formulations are fixed and cannot be changed to other vitamins or combinations at this time.
Questions or Concerns
If you have questions you can reach us anytime through the Messenger widget in the bottom-left corner or by emailing [email protected]. Our team can guide you step by step.