Understanding Beyond-Use Dates (BUD) for Compounded Tirzepatide and Semaglutide
Compounded medications have specific beyond-use dates (BUD), which indicate how long the product remains safe and effective for use. The BUD can vary depending on the medication, compounding process, and storage conditions. This article explores the general BUD guidelines for compounded tirzepatide and semaglutide.
General Beyond-Use Dates
For compounded versions of these medications, the typical BUDs are as follows:
Tirzepatide: Approximately 9–12 months
Semaglutide: Approximately 5–6 months.
Important Notes About BUDs
The specific BUD for a batch is usually indicated on the medication label. Always confirm this information with your pharmacist.
These timelines refer to medications stored under recommended conditions (e.g., proper refrigeration). Deviations may affect the stability and efficacy.
Factors Influencing BUD
BUDs can vary by batch, reflecting differences in compounding methods and stability testing. Although the ranges provided above are typical, users are strongly encouraged to:
Check the labeled expiration or BUD date provided with their prescription.
Store the medications as instructed, ideally following the temperature specifications recommended by the compounding pharmacy to maximize effectiveness and safety.
Safe Use of Multi-Dose Vials and Extended Durations
In some cases, you may notice instructions to discard the vial 28 days after first use. While this is a general guideline validated by manufacturers to ensure sterility, compounded medications may be verified by pharmacies to remain stable and effective for a longer period (e.g., 6 months) after opening. Pharmacies conduct safety and stability tests that allow multi-month supplies to be dispensed in single vials. When using multi-dose vials:
Always use a new, sterile needle for each injection.
Keep the vial clean and stored under appropriate conditions to maintain its sterility and effectiveness.
Follow the specific instructions provided by your pharmacist.
Final Guidance and Best Practices
Always rely on the specific instructions provided with your compounded medication, as variations in compounding processes may result in different BUDs even for the same medication.
Dispose of any medication that surpasses its labeled BUD or exhibits changes in appearance, smell, or consistency.
If you have further concerns or questions about your medication’s usage safety, consult your pharmacist or healthcare provider.
By following these guidelines, you can ensure the safe and effective use of compounded tirzepatide and semaglutide.